EASL Campus

A 36-year old man was found to be HBsAg positive 10 years ago. His recent tests are: ΑLΤ 36 IU/L, AST 25 IU/L, platelets 225,000/mm³, HBsAg positive, HBeAg negative, anti-HBe positive, HBV DNA 5,300 IU/mL, liver stiffness 6.6 kPa, normal ultrasonography of upper abdomen.

Which is the recommended management according to the recommendations of the EASL 2025 HBV guidelines?

A. Ask for HBsAg levels, as they will affect his management

B. ALT and HBV DNA measurements every 6 months, HBsAg levels every 12 months and liver stiffness measurements every 12-24 months for at least 3 years

C. ALT and HBV DNA measurements every 2 months, HBsAg levels every 6 months and liver stiffness measurements every 12 months for the first year

D. Start pegylated interferon-alfa therapy

E. Start entecavir or tenofovir